Paul Smolen , Douglas A . Baxter and John H . Byrne emerge from models of genetic regulatory systems
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چکیده
[Full Text] [Abstract] , October 1, 1999; 277 (4): C777-790. Am J Physiol Cell Physiol P. Smolen, D. A. Baxter and J. H. Byrne regulatory systems Effects of macromolecular transport and stochastic fluctuations on dynamics of genetic [PDF] [Full Text] [Abstract] , January 1, 2002; 9 (1): 29-40. Learn. Mem. M. A. Sutton, J. Ide, S. E. Masters and T. J. Carew Long-Term Memory for Sensitization in Aplysia Interaction between Amount and Pattern of Training in the Induction of Intermediateand [PDF] [Full Text] [Abstract] , May 15, 2002; 22 (10): 4132-4141. J. Neurosci. M. L. Wainwright, H. Zhang, J. H. Byrne and L. J. Cleary Localized Neuronal Outgrowth Induced by Long-Term Sensitization Training in Aplysia
منابع مشابه
Paul Smolen , Douglas A . Baxter and John H . Byrne emerge from models of genetic regulatory systems Frequency selectivity , multistability , and oscillations
[PDF] [Full Text] [Abstract] , October 1, 1999; 277 (4): C777-C790. Am J Physiol Cell Physiol P. Smolen, D. A. Baxter and J. H. Byrne regulatory systems Effects of macromolecular transport and stochastic fluctuations on dynamics of genetic [PDF] [Full Text] [Abstract] , January 1, 2002; 9 (1): 29-40. Learn. Mem. M. A. Sutton, J. Ide, S. E. Masters and T. J. Carew Long-Term Memory for Sensit...
متن کاملmodeling in physiology Frequency selectivity, multistability, and oscillations emerge from models of genetic regulatory systems
Smolen, Paul, Douglas A. Baxter, and John H. Byrne. Frequency selectivity, multistability, and oscillations emerge from models of genetic regulatory systems. Am. J. Physiol. 274 (Cell Physiol. 43): C531–C542, 1998.—To examine the capability of genetic regulatory systems for complex dynamic activity, we developed simple kinetic models that incorporate known features of these systems. These inclu...
متن کاملFrequency selectivity, multistability, and oscillations emerge from models of genetic regulatory systems.
To examine the capability of genetic regulatory systems for complex dynamic activity, we developed simple kinetic models that incorporate known features of these systems. These include autoregulation and stimulus-dependent phosphorylation of transcription factors (TFs), dimerization of TFs, crosstalk, and feedback. The simplest model manifested multiple stable steady states, and brief perturbat...
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well suited for predicting the effects of nonlinear interacPaul Smolen, Douglas A. Baxter, tions such as those dependent on oligomerization of and John H. Byrne* TFs, and for predicting the effects of biochemical time Department of Neurobiology and Anatomy delays, such as are required for intracellular transport W.M. Keck Center for the Neurobiology of Learning of macromolecules. Thus, for a sp...
متن کاملEffects of macromolecular transport and stochastic fluctuations on dynamics of genetic regulatory systems.
To predict the dynamics of genetic regulation, it may be necessary to consider macromolecular transport and stochastic fluctuations in macromolecule numbers. Transport can be diffusive or active, and in some cases a time delay might suffice to model active transport. We characterize major differences in the dynamics of model genetic systems when diffusive transport of mRNA and protein was compa...
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